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“Micro‐dose” Chlormadinone Acetate
Author(s) -
Seddon R. J.,
Black E. R.
Publication year - 1972
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1972.tb02336.x
Subject(s) - chlormadinone acetate , accidental , medicine , pregnancy , family planning , pediatrics , obstetrics , population , research methodology , physics , environmental health , biology , acoustics , genetics
SUMMARY Chlormadinone acetate 0.5 mg. was administered daily for a total of 6,036 weeks to 209 women attending the Auckland clinics of the Family Planning Association. Seventy‐five women discontinued the trial for reasons which included accidental pregnancy (2), planning pregnancy (6), increased frequency of bleeding (11) and cases lost to follow‐up (1). One of the two accidental pregnancies occurred during a cycle in which some tablets were omitted. The distribution of the intervals between bleeding episodes followed a bimodal pattern during the first 12 weeks of treatment. After the 13th week the interbleeding interval was maximal between 25 and 33 days. Headache was the commonest symptom during the trial but accounted for only one patient withdrawal.