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Experimental Immunization Against Human Placental Antigens
Author(s) -
Jones W. R.,
Ing R. M. Y.,
Kaye M. D.
Publication year - 1972
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1972.tb00512.x
Subject(s) - immunogenicity , syncytiotrophoblast , cytotrophoblast , antigen , immunization , placenta , immunology , biology , chorionic villi , pregnancy , fetus , genetics
Summary: The immunogenicity of human placental homogenates was studied in an experimental xenogeneic immunization system using the rabbit. The results provided evidence of the immunogenicity of certain non‐cellular and stromal elements of chorionic villi and of some cytotrophoblastic components. By contrast, a lack of immunogenicity of syncytiotrophoblast in this system demonstrates the relative antigenic “inertness” of this layer and suggests for it a possible role in providing a degree of immunological protection for the more immunogenic components, including cytotrophoblast, which it encompasses within the chorionic villus.