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Human Pregnancy – An Experimental Model for the Study of Immunological Disease
Author(s) -
Jones W.
Publication year - 1971
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1971.tb00471.x
Subject(s) - immunology , pregnancy , medicine , etiology , myasthenia gravis , pathogenesis , disease , thrombocytopenic purpura , immune system , serology , scleroderma (fungus) , fetus , antibody , pathology , biology , genetics , inoculation
Summary : The paradoxical survival of the mammalian fetus as an allograft provides a useful experimental model in immunology. In human pregnancy, studies of the placental transmission of serological and clinical manifestations of maternal auto‐immune diseases have resulted in important discoveries concerning the aetiology and pathogenesis of these conditions. These studies are reviewed with particular reference to thyrotoxicosis, myasthenia gravis, idiopathic thrombocytopenic purpura, systemic lupus erythematosus, scleroderma and pernicious anaemia.