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A Review of 50 Cases of Primary Amenorrhoea
Author(s) -
Evans James H.
Publication year - 1971
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1971.tb00443.x
Subject(s) - buccal swab , abnormality , chromosomal abnormality , etiology , gynecology , pregnancy , medicine , physiology , fertility , urinary system , obstetrics , karyotype , biology , chromosome , population , genetics , environmental health , psychiatry , gene
Summary: Fifty cases of primary amenorrhoea are reviewed with reference to the aetiology. In all patients the buccal smear chromatin complement was measured and chromosomal study proceeded to if this revealed less than 25% of cells to be chromatin positive. Total urinary gonadotrophin and oestrogen assays were performed in all patients and the spectrum of values seen is presented. The most common cause was chromosomal abnormality (24%). Although investigation to the extent performed is often not necessary to establish a precise diagnosis, such study is indicated to assess gonadal potential and subsequent fertility potential. In the present series, 31 (62%) patients were potentially fertile. With rational and physiological therapy all patients should be capable of leading normal, sexually active lives. To the present time, pregnancy has resulted from gonadotrophin therapy in the 5 patients in whom it has been indicated.