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Antidiuretic Effects of Oxytocin, Morphine and Pethidine in Pregnancy and Labour
Author(s) -
Liggins G. C.
Publication year - 1963
Publication title -
australian and new zealand journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.734
H-Index - 65
eISSN - 1479-828X
pISSN - 0004-8666
DOI - 10.1111/j.1479-828x.1963.tb00223.x
Subject(s) - pethidine , antidiuretic , diuresis , oxytocin , morphine , medicine , urine output , pregnancy , anesthesia , endocrinology , vasopressin , renal function , analgesic , biology , genetics
Summary: Diuresis was induced by a constant intravenous water load in women in late pregnancy and early labour. The effects on urine flow and clearance values of synthetic oxytocin (Syntocinon), morphine and pethidine were studied after their intravenous administration. Oxytocin caused a consistent antidiuretic response when given in doses above 20 mU/min. Morphine and pethidine also caused a marked antidiuresis which persisted for about 7 hours and 2 hours respectively. The onset of painful uterine contractions was not associated with inhibition of diuresis.