Open AccessInnate immunity and systemic lupus erythematosus
Author(s) -
JIN Ou,
SUN Lingyun,
KAVIKONDALA Sushma,
LAU ChakSing
Publication year - 2006
Publication title -
aplar journal of rheumatology
Language(s) - English
Resource type - Journals
eISSN - 1479-8077
pISSN - 0219-0494
DOI - 10.1111/j.1479-8077.2006.00229.x
Subject(s) - innate immune system , immunology , medicine , immunity , immune system
Innate immunity is the first‐line host defence against pathogens and damaged host cells, and the major cellular components are phagocytes such as monocytes/macrophages, polymorphonuclear cells and dendritic cells. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the loss of tolerance to self‐antigens, the source of which has been suggested to be apoptotic cells. In this article, we will review studies on apoptosis in SLE and discuss the contribution of innate immunity abnormalities in the development of this condition.