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Synthesis and application of some novel antimicrobial monoazonaphthalimide dyes: synthesis and characterisation
Author(s) -
Shaki Hanieh,
Gharanjig Kamaladin,
Rouhani Shohre,
Khosravi Alireza,
Fakhar Javad
Publication year - 2012
Publication title -
coloration technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 49
eISSN - 1478-4408
pISSN - 1472-3581
DOI - 10.1111/j.1478-4408.2012.00374.x
Subject(s) - thin layer chromatography , chemistry , acetanilide , column chromatography , bacillus subtilis , toluidine , nuclear chemistry , antibacterial activity , antimicrobial , escherichia coli , candida albicans , minimum inhibitory concentration , pyridine , proton nmr , chromatography , organic chemistry , bacteria , microbiology and biotechnology , biochemistry , biology , gene , genetics
A series of novel monoazo dyes based on N ‐pyridine‐1,8‐naphthalimides were prepared using 4‐amino‐ N ‐2‐aminomethylpyridine‐1,8‐naphthalimide as the diazo component and N , N ‐diethyl‐meta‐toluidine, 3‐( N , N ‐diethylamino)acetanilide and N ‐hydroxyethyl‐ N ‐ethylaniline as the coupling components. The synthesised dyes were purified by utilising column and preparative thin‐layer chromatography methods. The characterisations of the prepared dyes were carried out by differential scanning calorimetery, thin‐layer chromatography ( R f values), Fourier Transform infrared, and proton and carbon nuclear magnetic resonance techniques. The in vitro antibacterial activity of the novel synthesised compounds against Escherichia coli , Staphylococcus aureus , Bacillus subtilis and their antifungal activity against Candida albicans were evaluated by use of conventional agar dilution procedures and a minimum inhibitory concentration. Some of these synthesised dyes demonstrated antibacterial activity against Gram‐positive bacteria in addition to antifungal activities.