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Synthesis and mutagenic properties of direct dyes from 4,4′‐diamino‐ p ‐terphenyl and 4,4′‐diamino‐ p ‐quaterphenyl
Author(s) -
Wang Jinlong,
Freeman Harold S,
Claxton Larry D
Publication year - 2007
Publication title -
coloration technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 49
eISSN - 1478-4408
pISSN - 1472-3581
DOI - 10.1111/j.1478-4408.2006.00059.x
Subject(s) - terphenyl , chemistry , congo red , electrospray mass spectrometry , mass spectrometry , microsome , salmonella , electrospray , stereochemistry , medicinal chemistry , organic chemistry , chromatography , biochemistry , in vitro , biology , bacteria , adsorption , genetics
Disazo direct dyes were synthesised using bis‐diazotisation and coupling reactions involving 4,4′‐diamino‐ p ‐terphenyl and 4,4′‐diamino‐ p ‐quaterphenyl. The formation of the target dyes was confirmed by electrospray mass spectrometry and their mutagenicity was examined in the Salmonella microsome assay using TA98 and TA100. While most of these dyes were clearly non‐mutagenic, results from the Prival modification of the standard assay showed that Congo Red and its homologue derived from 4,4′‐diamino‐ p ‐terphenyl were clearly mutagenic.