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Mechanism of Reaction of Proteins with Reactive Dyes:II—Reactivity of Simple Model Compounds with Chlorotriazine Dyes
Author(s) -
SHORE J.
Publication year - 1968
Publication title -
journal of the society of dyers and colourists
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 49
eISSN - 1478-4408
pISSN - 0037-9859
DOI - 10.1111/j.1478-4408.1968.tb02838.x
Subject(s) - chemistry , nucleophile , anhydrous , histidine , reactivity (psychology) , cysteine , amino acid , imidazole , organic chemistry , serine , thiol , aqueous solution , lysine , combinatorial chemistry , polymer chemistry , biochemistry , medicine , alternative medicine , pathology , enzyme , catalysis
The chemistry of the functional groups in wool is described and the selection of appropriate model compounds for them is discussed. The measurement of the reactivities of these model compounds and possible mechanisms of their reactions are discussed. The nucleophilic anion is the important species in the reaction of a chlorotriazine dye with the thiol group in cysteine or the hydroxyl and phenolic groups in serine, threonine and tyrosineresidues. The reaction of a chlorotriazine dye with the amino groups of lysine and the N ‐terminal amino acids, with the imidazole group of histidine and with the guanidinogroup of arginine takes place mainly with the unprotonated base. Evidence in support of these mechanisms is provided by an investigation of the reactions of the dye with aqueous ammonia and anhydrous liquid ammonia.