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Relative Rates of Reduction of a Series of Azo Compounds
Author(s) -
Warwick G. P.
Publication year - 1959
Publication title -
journal of the society of dyers and colourists
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 49
eISSN - 1478-4408
pISSN - 0037-9859
DOI - 10.1111/j.1478-4408.1959.tb02328.x
Subject(s) - chemistry , hydrazine (antidepressant) , azobenzene , xanthine oxidase , xanthine , ring (chemistry) , chloride , combinatorial chemistry , medicinal chemistry , organic chemistry , molecule , biochemistry , enzyme
The chemistry and the pharmacology of the nitrogen “mustards” are briefly summarised, and the importance of azo compounds in cancer research is indicated. The concept of “latent activity” is introduced, and special attention is devoted to the p ‐phenylazo derivatives of NN ‐bischloroethylaniline as examples of such compounds used in the chemotherapy of cancer. The literature concerning the rates of reduction of azo compounds is briefly reviewed. The rates of reduction of some derivatives of 4– NN ‐bis‐2″‐chloroethylamino‐azobenzene with stannous chloride, hydrazine, and the xanthine—xanthine oxidase system are discussed in relation to the electronic character of ring substituents; attention is drawn to certain anomalous “ ortho ” effects. The rates of reduction are discussed also in relation to the observed tumour‐growth‐inhibiting properties of the compounds.