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Current limits and future challenges in the management of renal dysfunction in patients with cirrhosis: report from the I nternational C lub of A scites
Author(s) -
Angeli Paolo,
Sanyal Arun,
Moller Soren,
Alessandria Carlo,
Gadano Adrian,
Kim Ray,
Sarin Shiv K.,
Bernardi Mauro
Publication year - 2013
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2012.02807.x
Subject(s) - cirrhosis , medicine , ascites , intensive care medicine , terlipressin , complication , hepatic dysfunction , hepatorenal syndrome , bioinformatics , biology
Advanced cirrhosis is often complicated by a multi organ failure syndrome which involves many different organs besides the liver. The high morbidity and mortality secondary to this clinical setting is often related to renal dysfunction, either alone or, more frequently, in combination with other organ dysfunction. A clear defintion of renal dysfunction, an accurate differential diagnostic process of its different phenotypes as well as of full understanding of its pathophysiological mechanisms are crucial to the development of strategies for the management of this complication. This article is based either on the more recent knowledge on renal dysfunction in advanced cirrhosis or current opinions among the members of the I nternational C lub of A scites ( ICA ) on the management of this complication, obtained through a survey and discussed during the EASL ‐ ICA J oint M eeting in B erlin in M arch 2011. It reviews critically our current knowledge and it outlines future perspectives, on the management of renal dysfunction in patients with cirrhosis.