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The significance of ICG‐R15 in predicting hepatic toxicity in patients receiving radiotherapy for hepatocellular carcinoma
Author(s) -
Yoon Hong In,
Koom Woong Sub,
Lee Ik Jae,
Jeong Kyoungkeun,
Chung Yoonsun,
Kim Ja Kyung,
Lee Kwan Sik,
Han KwangHyub,
Seong Jinsil
Publication year - 2012
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2012.02784.x
Subject(s) - medicine , hepatocellular carcinoma , incidence (geometry) , univariate analysis , gastroenterology , indocyanine green , oncology , radiation therapy , multivariate analysis , surgery , physics , optics
Aim To evaluate whether the retention rate of indocyanine green 15 min after administration ( ICG ‐R15) could predict radiation hepatotoxicity in patients treated with radiotherapy ( RT ) for hepatocellular carcinoma ( HCC ). Methods We retrospectively reviewed data of 146 HCC patients treated with RT between February 1994 and December 2008. The ICG ‐R15 was measured within 1 month prior to the start of RT . Radiation hepatotoxicity was evaluated by incidence of radiation‐induced liver disease ( RILD ) between 2 weeks and 3 months after completion of RT . We analysed the correlation between the incidence rate of RILD and the ICG ‐R15 before RT (pre‐ RT ICG ‐R15). Results The classic and non‐classic RILD occurred in 15 patients (10.3%): classic type in five patients (3.4%) and non‐classic RILD in 10 patients (6.9%). A positive correlation was shown between the probability of RILD and increase in pre‐ RT ICG ‐R15 ( P < 0.0001). Univariate analysis indicated that cut‐off value of pre‐ RT ICG ‐R15 could predict RILD significantly. The incidence of RILD for the patients with 22% or higher pre‐ RT ICG ‐R15 levels was 40.7% as compared to 3.4% for those with levels lower than 22% ( P < 0.0001). There was no clinical factor that significantly affected RILD in univariate analysis. Multivariate analysis indicated that the pre‐ RT ICG ‐R15 value was the only significant factor affecting RILD ( P < 0.0001). Conclusion These results suggest that pre‐ RT ICG ‐R15 could be a useful factor in predicting radiation hepatotoxicity in HCC patients treated with RT .