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Hepatic iron overload following liver transplantation of a C282y homozygous allograft: a case report and literature review
Author(s) -
Dwyer Jeremy P.,
Sarwar Shahzad,
Egan Brian,
Nolan Niamh,
Hegarty John
Publication year - 2011
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2011.02606.x
Subject(s) - hemochromatosis , liver biopsy , medicine , liver transplantation , pathology , transplantation , gastroenterology , hereditary hemochromatosis , biopsy
Hereditary haemochromatosis is a common genetic disease associated with progressive iron overload and parenchymal organ damage including liver, pancreas and heart. We report a case of inadvertent transplantation of a liver from a haemochromatosis donor to a 56‐year‐old A sian female. Progressive iron overload occurred over a 2 year follow up as assessed by liver biopsy and iron studies in the absence of a secondary cause of iron overload, supporting a primary role of liver rather than small intestine in the regulation of iron homeostasis in hereditary haemochromatosis.