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New insights into the management of hepato‐renal syndrome
Author(s) -
Hasper Dietrich,
Jörres Achim
Publication year - 2011
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2011.02586.x
Subject(s) - terlipressin , midodrine , medicine , intensive care medicine , extracorporeal , hepatorenal syndrome , gold standard (test) , clinical trial , complication , blood pressure , cirrhosis , orthostatic vital signs
Hepato‐renal syndrome (HRS) is a serious complication in patients with advanced liver disease indicating a very poor prognosis. Nevertheless, effective treatment strategies have been introduced into clinical practice over the last decade. The combined treatment with terlipressin/albumin has been proven to be effective in most published studies and should be regarded as the standard of care. Norepinephrine or midodrine are possible alternatives when terlipressin is not available. Although there is presently not enough evidence to recommend extracorporeal liver support therapy as a standard procedure in patients with HRS, these concepts constitute promising options that need to be studied in prospective clinical trials.