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Association of mannose‐binding lectin‐2 gene polymorphism with the development of hepatitis C‐induced hepatocellular carcinoma
Author(s) -
Eurich Dennis,
BoasKnoop Sabine,
Morawietz Lars,
Neuhaus Ruth,
Somasundaram Rajan,
Ruehl Martin,
Neumann Ulf P.,
Neuhaus Peter,
Bahra Marcus,
Seehofer Daniel
Publication year - 2011
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2011.02522.x
Subject(s) - mannan binding lectin , hepatocellular carcinoma , lectin , gene , mannose , biology , genetics , immunology , biochemistry
Background: Development of end‐stage liver and graft disease is suspected to be partially determined by the individual genetic background. Mannose‐binding lectin (MBL) is an important immunomodulatory factor, which is supposed to be involved in complement activation and oncogenesis. Genetic polymorphisms of MBL‐2 alter MBL functionality. The aim of our study was to determine the prevalence of MBL‐2 polymorphism (rs7096206) in hepatitis C virus (HCV)‐induced hepatocellular carcinoma (HCC) based on histological analysis of explanted livers in patients undergoing liver transplantation (LT). Methods: One hundred and seventy‐seven patients, who underwent LT for HCV‐induced liver disease, were genotyped for MBL‐2 by TaqMan genotyping assay. Sixty‐two patients with histologically confirmed HCC were compared with 115 patients without HCC. MBL‐2 genotypes were corelated with the growth patern, tumour size and pretransplant α‐fetoprotein (AFP) level of HCC patients. Results: The prevalence of GG/GC genotypes was significantly higher among HCC patients compared with tumour‐free explanted livers ( P =0.004; odds ratio 2.5; 1.3–4.8). GG/GC genotype group was significantly associated with the size of HCC ( P =0.022), higher pretransplant AFP level ( P =0.010) and bilobar tumour growth ( P =0.038). Furthermore, CC genotype was found to be significantly more frequent in AFP‐negative HCCs ( P =0.002). Conclusion: Mannose‐binding lectin‐2 polymorphism seems to be involved in the development of pretransplant HCV‐induced HCC and should be further investigated as potential risk factor for HCV‐associated carcinogenesis.