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Cell‐mediated immune responses to α‐fetoprotein and other antigens in hepatocellular carcinoma
Author(s) -
Behboudi Shahriar,
Boswell Sandra,
Williams Roger
Publication year - 2010
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2009.02194.x
Subject(s) - immune system , antigen , cytotoxic t cell , immunology , immunotherapy , cd8 , effector , major histocompatibility complex , biology , hepatocellular carcinoma , acquired immune system , cellular immunity , t cell , cancer research , in vitro , biochemistry
Cell‐mediated immune responses play an important role in the control of tumour growth. CD4 and CD8 T cells recognise tumour antigens presented via major histocompatibility complex molecules of antigen presenting cells and develop into effector cells with the ability to identify and kill tumour cells. Here, we re‐examine the adaptive immune response to tumour antigens expressed by hepatocellular carcinoma (HCC) and discuss approaches that could be applied in future T‐cell‐based immunotherapy schedules to induce a potent and effective antitumour immunity. Moreover, we discuss cytotoxic T lymphocyte and Th1 responses to tumour antigens in patients with HCC and evaluate the effects of conventional treatments on antitumour T‐cell responses.