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Teucrium polium in prevention of steatohepatitis in rats
Author(s) -
Amini Rahim,
Nosrati Narges,
Yazdanparast Razieh,
Molaei Mahsa
Publication year - 2009
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2009.02033.x
Subject(s) - alkaline phosphatase , superoxide dismutase , glutathione peroxidase , methionine , steatosis , medicine , nonalcoholic steatohepatitis , antioxidant , chemistry , steatohepatitis , endocrinology , nonalcoholic fatty liver disease , biochemistry , oxidative stress , enzyme , fatty liver , amino acid , disease
Background: In this study, we tried to evaluate whether the ethyl acetate (EtOAc) extract of Teucrium polium , with a high antioxidant activity, is able to prevent the incidence of nonalcoholic steatohepatitis. Methods: Nonalcoholic steatohepatitis was induced in male N‐Mary rats using a methionine/choline‐deficient (MCD) diet. Rats were given normal diet (A), normal diet+EtOAc extract (B), MCD diet (C) and MCD diet+EtOAc (D). Results: The MCD diet led to grade 1 liver steatosis, inflammation and ballooning degeneration. In group D, these factors abated to grade 0 in 80% of the rats. In groups receiving the EtOAc extract, lipoprotein profiles had significantly improved relative to those not receiving the extract. Also, a dramatic reduction was observed in the sera alkaline phosphatase, aspartate aminotransferase and alanine aminoteransferase activities. The activities of the liver superoxide dismutase, glutathione peroxidase and glutathione reductase enzymes were also enhanced. Conclusion: The EtOAc extract could reverse the adverse effects of the MCD diet.