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Plasmatic vitamin C in nontreated hepatitis C patients is negatively associated with aspartate aminotransferase
Author(s) -
Souza dos Santos Rosane M.,
De Bem Andreza F.,
Colpo Elisângela,
Bertoncello Iara,
Nogueira Cristina W.,
Rocha João B. T.
Publication year - 2008
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2007.01599.x
Subject(s) - hepatitis c , medicine , gastroenterology , vitamin c , hepatitis , aspartate aminotransferases , vitamin , chemistry , endocrinology , alanine transaminase
Objectives: To evaluate the possible relationship between aminotransferases levels and markers of oxidative stress in chronic hepatitis C patients. Design and methods: Patients without treatment for hepatitis were divided in to group I (15–39 U/L); group II (41–76 U/L) and group III (81–311 U/L) of activity alanine aminotransferase (ALT). Blood markers of oxidative stress [catalase (CAT), glutathione peroxidase (GPx), thiobarbituric acid‐reactive species (TBARS), nonprotein and protein thiol (NP‐SH and P‐SH) groups and vitamin C] were determined. Results: P‐SH and NP‐SH levels, TBARS, GPx and CAT were not different between groups. Vitamin C was significantly decreased in groups II ( P =0.03) and III ( P =0.001) when compared with group I and correlated negatively with aspartate aminotransferase (AST; r =−0.29, P =0.042). Conclusion: Vitamin C levels were negatively associated with AST, suggesting that vitamin C could be an additional indicator of hepatitis C severity.