Premium
Acute hepatitis in a patient with familial Mediterranean fever
Author(s) -
Migita Kiyoshi,
Abiru Seigo,
Tanaka Mototsugu,
Ito Masahiro,
Miyashita Taichiro,
Maeda Yumi,
Koga Tomohiro,
Nakamura Minoru,
Komori Atsumasa,
Yatsuhashi Hiroshi,
Ida Hiroaki,
Eguchi Katsumi,
Hirayama Kenji,
Yasunami Michio,
Ishibashi Hiromi
Publication year - 2008
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2007.01598.x
Subject(s) - familial mediterranean fever , serositis , mefv , medicine , hepatitis , liver biopsy , pathology , pyrin domain , liver function tests , colchicine , inflammation , gastroenterology , biopsy , biology , gene mutation , mutation , disease , gene , inflammasome , biochemistry
Familial Mediterranean fever (FMF) is a hereditary syndrome characterized by recurrent episodes of fever and serositis. In this report, we describe a Japanese patient with FMF and Sjögren's syndrome, in whom acute elevations of transaminase occurred. The histological findings from the liver biopsy specimens demonstrated a nonspecific hepatitis, with liver cell necrosis and interlobular inflammatory cell invasion, without the presence of interface hepatitis or bile duct injury. This case underscores the possibility that MEFV mutations contribute to hepatic inflammation, as seen in this case, by way of an alteration of the pyrin function.