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Current concepts in the pathogenesis of nonalcoholic fatty liver disease
Author(s) -
MéndezSánchez Nahum,
Arrese Marco,
ZamoraValdés Daniel,
Uribe Misael
Publication year - 2007
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2007.01483.x
Subject(s) - nonalcoholic fatty liver disease , pathogenesis , nonalcoholic steatohepatitis , medicine , fatty liver , disease , gastroenterology , intensive care medicine
Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of chronic liver disease, representing the leading cause of hepatology referral in some centres. However, its pathophysiology is not completely understood. Insulin resistance is one of the major mechanisms involved in disease prevalence and progression. Owing to the lack of an effective pharmacological therapy, recommendations on treatment are scarce and are based mainly on lifestyle changes, including diet and exercise. A review of the current literature on pathogenesis of NAFLD is presented in this article.