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Hepatitis B‐associated vasculitis in Alaska Natives: viral genotype, clinical and serologic outcome
Author(s) -
Hurlburt Kathy J.,
McMahon Brian J.,
Simonetti Josephine P.,
Livingston Stephen E.,
Bulkow Lisa R.,
Snowball Mary M.,
Chulanov Vladimir P.,
Nainan Omana P.,
Williams James L.
Publication year - 2007
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2007.01473.x
Subject(s) - vasculitis , medicine , hepatitis b virus , genotype , population , hepatitis b , immunology , incidence (geometry) , genotyping , virology , virus , biology , disease , gene , biochemistry , physics , environmental health , optics
Background: The highest incidence of hepatitis B virus (HBV)‐associated vasculitis in the world has been reported in Alaska Natives. We examined the incidence of HBV‐associated vasculitis before and after mass HBV vaccine immunization and the association between HBV genotype and vasculitis in a population‐based cohort study in Alaska natives chronically infected with HBV. Methods: Genotyping was performed in vasculitis cases and 644 hepatitis B‐positive controls without vasculitis using polymerase chain reaction and sequencing of the S gene. Occurrence of HBV vasculitis from 1974 to 2004 was calculated. HBV vasculitis patients and controls were also tested for basal core promoter and precore mutations. Results: Fifteen cases of HBV‐associated vasculitis were identified: 13 (86%) had genotype D and one each genotype A and F. Genotype D was more commonly found in patients with vasculitis than controls [odd ratio (OR)=5.9, confidence interval (95% CI) 1.2, 21.8; P <0.015). Conclusions: HBV‐associated vasculitis was associated with genotype D.