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A novel therapeutic drug (copper nicotinic acid complex) for non‐alcoholic fatty liver
Author(s) -
Salama Ragaa H. M.,
Nassar Ahmed Y. A.,
Nafady Allam A. M.,
Mohamed Hesham H. T.
Publication year - 2007
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2007.01460.x
Subject(s) - fatty liver , nitric oxide , alkaline phosphatase , medicine , superoxide dismutase , glutathione , alcoholic fatty liver , liver function , chemistry , oxidative stress , fatty acid , endocrinology , biochemistry , enzyme , disease
Background: Fatty liver is the accumulation of fat in liver cells, which leads to disruption of the normal liver structure and function. Methods: A non‐alcoholic fatty liver rat model received copper (Cu) (I)‐nicotinate complex [CuCl(HNA)2] for 4 weeks. Results: Clinical signs and histopathological examinations showed obvious improvements in rats that received Cu complex who were continuously on an (HCFF) diet than those returned to standard diet with Cu complex. The improvement was matched in total lipids in sera and hepatic tissue, with disappearance of fat droplets from liver sections. Furthermore, the gain in body weight and the corresponding decrease in liver weight, decreased liver transaminases and alkaline phosphatase were prominent. The oxidative stress markers such as nitric oxide, lipid peroxides, glutathione and superoxide dismutase were obviously changed to healthy normal levels. Conclusion: The Cu complex may serve as a novel chemical restoring agent in fatty degenerated liver cells and for renewal of their structure and functions. However, clinical trials are required for more evaluation of the Cu complex in humans.