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Ring‐shaped appearance in liver‐specific image with Levovist: a characteristic enhancement pattern for hypervascular benign nodule in the liver of heavy drinkers
Author(s) -
Maruyama Hitoshi,
Matsutani Shoichi,
Kondo Fukuo,
Yoshizumi Hiroaki,
Kobayashi Satoshi,
Okugawa Hidehiro,
Ebara Masaaki,
Saisho Hiromitsu
Publication year - 2006
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2006.01286.x
Subject(s) - medicine , nodule (geology) , radiology , differential diagnosis , magnetic resonance imaging , pathological , ultrasound , pathology , paleontology , biology
Background/Aims: The aim was to clarify the features of contrast‐enhanced ultrasound (CEUS) with Levovist for diagnosis of hypervascular benign nodules in the liver of heavy drinkers. Patients and methods: Seven heavy drinkers with hypervascular nodules in the liver were studied. Findings of CEUS with Levovist (wide‐band Doppler, 7/7), contrast‐enhanced computed tomography (CECT, 7/7) and magnetic resonance imaging (MRI, 5/7) were compared for one nodule in each patient. Results: Diagnosis of all seven nodules on CECT was HCC, whereas pathological results were HCC for four nodules and benign lesion for three nodules. The former four showed compatible findings for HCC on CEUS (4/4) and MRI (2/4). However, the latter three showed characteristic liver‐specific sonograms with a ring‐shaped appearance – peripheral enhancement with a central non‐enhanced area. Two of the three nodules showed decreased signal‐intensity in the periphery on SPIO‐enhanced MRI. Conclusions: The ring‐shaped appearance on liver‐specific sonograms with Levovist may be a useful sign for the differential diagnosis of hypervascular benign nodule from HCC in heavy drinkers.