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Clinical and prognostic role of plasma coagulation factor XIII activity for bleeding disorders and 6‐year survival in patients with chronic liver disease
Author(s) -
Tacke Frank,
Fiedler Kai,
Depka Mario,
Luedde Tom,
Hecker Hartmut,
Manns Michael P.,
Ganser Arnold,
Trautwein Christian
Publication year - 2006
Publication title -
liver international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.873
H-Index - 110
eISSN - 1478-3231
pISSN - 1478-3223
DOI - 10.1111/j.1478-3231.2005.01205.x
Subject(s) - medicine , cirrhosis , gastroenterology , factor xiii , liver transplantation , prothrombin time , liver disease , coagulation , chronic liver disease , clotting factor , partial thromboplastin time , factor vii , coagulation disorder , risk factor , transplantation , fibrinogen
Background/Aims: Alterations of plasma coagulation factor XIII may contribute to bleeding disorders in patients with liver cirrhosis. As standard clotting tests such as prothrombin time or activated thromboplastin time (aPTT) cannot detect factor XIII deficiency, this may often be overlooked in clinical practice. We aimed to define factor XIII's clinical and prognostic role in chronic liver disease. Patients and methods: Factor XIII activities were assessed among various other parameters in 111 patients with chronic liver diseases during evaluation for liver transplantation in a prospective study. Results: Unlike coagulation factors II, V or VII, factor XIII activity was maintained in the majority of patients with liver cirrhosis. However, although rarely, factor XIII deficiencies (<50%) occurred, especially in Child C cirrhosis. Factor XIII levels correlated with liver's biosynthetic capacity (cholinesterase activity, albumin, total protein) as well as with platelet count, global coagulation tests and other single coagulation factors. Patients reporting a current systemic bleeding tendency at study entry had significantly reduced factor XIII. In a 6‐year follow‐up, patients with factor XIII <50% had a significantly increased risk of severe upper gastrointestinal bleed, and reduced factor XIII (<50%, 50–75% vs. normal) was associated with increased mortality. Conclusions: Factor XIII deficiency is rare in patients with liver cirrhosis, but is associated with a clinical bleeding tendency and an unfavorable prognosis for future hemorrhages and survival.