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Comparison between l ‐CHOP and an l ‐CHOP protocol with interposed treatments of CCNU and MOPP ( l ‐CHOP‐CCNU‐MOPP) for lymphoma in dogs
Author(s) -
Rassnick K. M.,
Bailey D. B.,
Malone E. K.,
Intile J. L.,
Kiselow M. A.,
Flory A. B.,
Barlow L. L.,
Balkman C. E.,
Barnard S. M.,
Waite A. H.
Publication year - 2010
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/j.1476-5829.2010.00224.x
Subject(s) - chop , medicine , gastroenterology , lymphoma , vincristine , lomustine , chemotherapy , cyclophosphamide
An l ‐CHOP protocol with interposed treatments of CCNU and MOPP ( l ‐CHOP‐CCNU‐MOPP) was evaluated in 66 dogs with stages III–V lymphoma. Results were compared with a historical group of 71 dogs treated with an l ‐CHOP protocol. Complete remission (CR) rates (85 and 80%, respectively) did not differ significantly between protocols ( P = 0.48). First CR duration for dogs treated with l ‐CHOP‐CCNU‐MOPP was significantly longer: median, 317 days; 2‐year CR rate, 35% versus median, 298 days; 2‐year CR rate, 13%, P = 0.05). For the l ‐CHOP‐CCNU‐MOPP protocol, dogs in substage‐b had a 4.3 times greater hazard of having a relapse than dogs in substage‐a ( P = 0.002). Frequency of adverse chemotherapy‐associated gastrointestinal effects did not differ between protocols ( P = 0.77). Neutropenia (primarily after CCNU) occurred more frequently in dogs treated with l ‐CHOP‐CCNU‐MOPP ( P < 0.001). In summary, the l ‐CHOP‐CCNU‐MOPP protocol showed an improved duration of first CR as compared with an l ‐CHOP protocol, but the relevance of this finding might be subject to clinical judgement.