Premium
Oncolytic gene therapy for canine cancers: teaching old dog viruses new tricks
Author(s) -
Arendt M.,
Nasir L.,
Morgan I. M.
Publication year - 2009
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/j.1476-5829.2009.00187.x
Subject(s) - oncolytic virus , canine distemper , virology , cancer , virus , cancer therapy , genetic enhancement , biology , cancer treatment , oncolytic adenovirus , cancer research , medicine , gene , genetics
The use of viruses to treat cancer has been studied for decades. With the advancement of molecular biology, viruses have been modified and genetically engineered to optimize their ability to target cancer cells. Canine viruses, such as distemper virus and adenovirus, are being exploited for the treatment of canine cancer as the dog has proven to be a good comparative model for human cancer research and proof of concept investigations. In this review, we introduce the concept of oncolytic viruses and describe some of the preliminary attempts to use oncolytic viruses for the treatment of canine cancer.