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Canine cutaneous epitheliotropic T‐cell lymphoma: a review
Author(s) -
Fontaine J.,
Bovens C.,
Bettenay S.,
Mueller R. S.
Publication year - 2009
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/j.1476-5829.2008.00176.x
Subject(s) - mycosis fungoides , cutaneous t cell lymphoma , cutaneous lymphoma , t cell lymphoma , lomustine , lymphoma , pathology , cd8 , dermatology , pagetoid , medicine , neoplastic disease , tropism , infiltration (hvac) , immunology , virus , chemotherapy , vincristine , immune system , immunohistochemistry , cyclophosphamide , physics , thermodynamics
Cutaneous epitheliotropic T‐cell lymphoma in the dog is a rare neoplastic condition with unknown aetiology. The dermatitis is characterized by infiltration of neoplastic T lymphocytes with a specific tropism for the epidermis and the adnexal structures. The different clinical and histological forms (mycosis fungoides, pagetoid reticulosis and Sézary syndrome) are reviewed. The disease in the dog resembles the human syndrome, but in 80% of the canine cases, neoplastic cells are CD4 − /CD8 + versus CD4 + /CD8 − in 90% of the human patients. Prognosis is poor with a survival time from few months to 2 years. Treatments frequently have a low efficacy. New protocols using lomustine may improve the poor prognosis of the disease.