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Interactions between radiation therapy and immunotherapy: the best of two worlds?
Author(s) -
Thamm D. H.
Publication year - 2006
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/j.1476-5829.2006.00110.x
Subject(s) - immunotherapy , effector , radiation therapy , function (biology) , cancer research , medicine , cell function , antigen , immunology , tumor microenvironment , cell , biology , immune system , microbiology and biotechnology , biochemistry
Contrary to earlier thought, there is now accumulating evidence that local radiation therapy and various form of immunotherapy may be complementary. This may occur as a result of radiation‐induced changes to the tumour cells themselves, the tumour microenvironment, the tumour vasculature and modulation of antigen‐presenting and effector cell function. This study discusses recent findings and potential applications of this apparent synergy.