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The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB 1 ‐ and FAAH ‐independent mechanisms
Author(s) -
Bosier Barbara,
Muccioli Giulio G,
Lambert Didier M
Publication year - 2013
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2012.02208.x
Subject(s) - anandamide , endocannabinoid system , fatty acid amide hydrolase , cannabinoid receptor , monoacylglycerol lipase , palmitoylethanolamide , 2 arachidonoylglycerol , chemistry , cannabidiol , cannabinoid , tyrosine hydroxylase , pharmacology , biochemistry , receptor , biology , enzyme , agonist , medicine , cannabis , psychiatry
Anandamide and 2-arachidonoylglycerol are neuromodulatory lipids interacting with cannabinoid receptors, whose availability is regulated by the balance between 'on demand' generation and enzymatic degradation [by fatty acid amide hydrolase (FAAH)/monoacylglycerol lipase]. Given the reported effects of anandamide on dopamine transmission, we investigated the influence of endocannabinoids and URB597, a well-known FAAH inhibitor, on the expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine synthesis.