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Cannabidivarin is anticonvulsant in mouse and rat
Author(s) -
Hill AJ,
Mercier MS,
Hill TDM,
Glyn SE,
Jones NA,
Yamasaki Y,
Futamura T,
Duncan M,
Stott CG,
Stephens GJ,
Williams CM,
Whalley BJ
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2012.02207.x
Subject(s) - anticonvulsant , pilocarpine , pharmacology , status epilepticus , phenobarbital , in vivo , seizure threshold , epilepsy , cannabidiol , chemistry , phenytoin , medicine , anesthesia , neuroscience , psychology , cannabis , biology , microbiology and biotechnology , psychiatry
Phytocannabinoids in Cannabis sativa have diverse pharmacological targets extending beyond cannabinoid receptors and several exert notable anticonvulsant effects. For the first time, we investigated the anticonvulsant profile of the phytocannabinoid cannabidivarin (CBDV) in vitro and in in vivo seizure models.