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Chronic blockade of CB 1 receptors reverses startle gating deficits and associated neurochemical alterations in rats reared in isolation
Author(s) -
Zamberletti E,
Piscitelli F,
Cadeddu F,
Rubino T,
Fratta W,
Fadda P,
Di Marzo V,
Parolaro D
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2012.02095.x
Subject(s) - am251 , prepulse inhibition , endocannabinoid system , neurochemical , dopamine , endocrinology , glutamate receptor , medicine , pharmacology , agonist , cannabinoid receptor , receptor , schizophrenia (object oriented programming) , psychiatry
Pharmacological interventions aimed at restoring the endocannabinoid system functionality have been proposed as potential tools in the treatment of schizophrenia. Based on our previous results suggesting a potential antipsychotic-like profile of the CB(1) receptor inverse agonist/antagonist, AM251, here we further investigated the effect of chronic AM251 administration on the alteration of the sensorimotor gating functions and endocannabinoid levels induced by isolation rearing in rats.