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Sexual dimorphism in rodent models of hypertension and atherosclerosis
Author(s) -
Bubb Kristen J,
Khambata Rayomand S,
Ahluwalia Amrita
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2012.02036.x
Subject(s) - disease , sexual dimorphism , rodent model , medicine , rodent , bioinformatics , intensive care medicine , gerontology , biology , pathology , ecology
Approximately one third of all deaths are attributed to cardiovascular disease (CVD), making it the biggest killer worldwide. Despite a number of therapeutic options available, the burden of CVD morbidity continues to grow indicating the need for continued research to address this unmet need. In this respect, investigation of the mechanisms underlying the protection that premenopausal females enjoy from cardiovascular‐related disease and mortality is of interest. In this review, we discuss the essential role that rodent animal models play in enabling this field of research. In particular, we focus our discussion on models of hypertension and atherosclerosis.