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Regional‐ and agonist‐dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists
Author(s) -
Broad J,
Mukherjee S,
Samadi M,
Martin JE,
Dukes GE,
Sanger GJ
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2012.02009.x
Subject(s) - motilin , myenteric plexus , medicine , antrum , endocrinology , cholinergic , choline acetyltransferase , agonist , biology , enteric nervous system , acetylcholine , chemistry , stomach , receptor , immunohistochemistry
Delayed gastric emptying is poorly managed. Motilin agonists are potential treatments but inadequate understanding into how enteric nerve functions are stimulated compromises drug/dose selection. Resolution is hampered by extreme species dependency so methods were developed to study human gastrointestinal neuromuscular activities and the neurobiology of motilin.