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The solute carrier 6 family of transporters
Author(s) -
Bröer Stefan,
Gether Ulrik
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2012.01975.x
Subject(s) - osmolyte , solute carrier family , transporter , neurotransmitter , neurotransmitter transporter , biology , excitatory amino acid transporter , neurotransmission , neuroscience , biochemistry , glutamate receptor , gene , central nervous system , receptor
The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.