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Curcumin inhibits gene expression of receptor for advanced glycation end‐products (RAGE) in hepatic stellate cells in vitro by elevating PPARγ activity and attenuating oxidative stress
Author(s) -
Lin Jianguo,
Tang Youcai,
Kang Qiaohua,
Feng Yunfeng,
Chen Anping
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2012.01910.x
Subject(s) - rage (emotion) , hepatic stellate cell , glycation , oxidative stress , chemistry , in vitro , receptor , curcumin , microbiology and biotechnology , pharmacology , biochemistry , biology , endocrinology , neuroscience
Diabetes is characterized by hyperglycaemia, which facilitates the formation of advanced glycation end-products (AGEs). Type 2 diabetes mellitus is commonly accompanied by non-alcoholic steatohepatitis, which could lead to hepatic fibrosis. Receptor for AGEs (RAGE) mediates effects of AGEs and is associated with increased oxidative stress, cell growth and inflammation. The phytochemical curcumin inhibits the activation of hepatic stellate cells (HSCs), the major effectors during hepatic fibrogenesis. The aim of this study was to explore the underlying mechanisms of curcumin in the elimination of the stimulating effects of AGEs on the activation of HSCs. We hypothesize that curcumin eliminates the effects of AGEs by suppressing gene expression of RAGE.