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The third extracellular loop of the human calcitonin receptor‐like receptor is crucial for the activation of adrenomedullin signalling
Author(s) -
Kuwasako Kenji,
Hay Debbie L,
Nagata Sayaka,
Hikosaka Tomomi,
Kitamura Kazuo,
Kato Johji
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01803.x
Subject(s) - g protein coupled receptor , adrenomedullin , receptor , calcitonin gene related peptide , microbiology and biotechnology , hek 293 cells , chemistry , calcitonin receptor , transfection , extracellular , calcitonin , biology , endocrinology , biochemistry , neuropeptide , gene
The extracellular loops (ECLs) in Family A GPCRs are important for ligand binding and receptor activation, but little is known about the function of Family B GPCR ECLs, especially ECL3. Calcitonin receptor-like receptor (CLR), a Family B GPCR, functions as a calcitonin gene-related peptide (CGRP) and an adrenomedullin (AM) receptor in association with three receptor activity-modifying proteins (RAMPs). Here, we examined the function of the ECL3 of human CLR within the CGRP and AM receptors.