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Differential signalling in human cannabinoid CB 1 receptors and their splice variants in autaptic hippocampal neurones
Author(s) -
Straiker Alex,
WagerMiller Jim,
Hutchens Jacqueline,
Mackie Ken
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01744.x
Subject(s) - cannabinoid , cannabinoid receptor , receptor , neuroscience , hippocampal formation , biology , neurotransmission , endocannabinoid system , cannabinoid receptor agonists , pharmacology , chemistry , biochemistry , agonist
Cannabinoids such as Δ(9) - tetrahydrocannabinol, the major psychoactive component of marijuana and hashish, primarily act via cannabinoid CB(1) and CB(2) receptors to produce characteristic behavioural effects in humans. Due to the tractability of rodent models for electrophysiological and behavioural studies, most of the studies of cannabinoid receptor action have used rodent cannabinoid receptors. While CB(1) receptors are relatively well-conserved among mammals, human CB(1) (hCB(1) ) differs from rCB(1) and mCB(1) receptors at 13 residues, which may result in differential signalling. In addition, two hCB(1) splice variants (hCB(1a) and hCB(1b) ) have been reported, diverging in their amino-termini relative to hCB(1) receptors. In this study, we have examined hCB(1) signalling in neurones.