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Pharmacological characterization of rat amylin receptors: implications for the identification of amylin receptor subtypes
Author(s) -
Bailey RJ,
Walker CS,
Ferner AH,
Loomes KM,
Prijic G,
Halim A,
Whiting L,
Phillips ARJ,
Hay DL
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01717.x
Subject(s) - amylin , receptor , calcitonin gene related peptide , agonist , calcitonin receptor , class c gpcr , endocrinology , adrenomedullin , medicine , pharmacology , chemistry , biology , biochemistry , neuropeptide , metabotropic receptor , insulin , islet
Amylin (Amy) is an important glucoregulatory peptide and AMY receptors are clinical targets for diabetes and obesity. Human (h) AMY receptor subtypes are complexes of the calcitonin (CT) receptor with receptor activity-modifying proteins (RAMPs); their rodent counterparts have not been characterized. To allow identification of the most clinically relevant receptor subtype, the elucidation of rat (r) AMY receptor pharmacology is necessary.