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Cannabidiol, a non‐psychotropic component of cannabis, attenuates vomiting and nausea‐like behaviour via indirect agonism of 5‐HT 1A somatodendritic autoreceptors in the dorsal raphe nucleus
Author(s) -
Rock EM,
Bolognini D,
Limebeer CL,
Cascio MG,
AnaviGoffer S,
Fletcher PJ,
Mechoulam R,
Pertwee RG,
Parker LA
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01621.x
Subject(s) - pharmacology , dorsal raphe nucleus , cannabidiol , nausea , chemistry , medicine , anesthesia , serotonin , receptor , cannabis , serotonergic , psychiatry
To evaluate the hypothesis that activation of somatodendritic 5-HT(1A) autoreceptors in the dorsal raphe nucleus (DRN) produces the anti-emetic/anti-nausea effects of cannabidiol (CBD), a primary non-psychoactive cannabinoid found in cannabis.