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Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy
Author(s) -
Andrade Daniele,
Serra Rafaela,
Svensjö Erik,
Lima Ana Paula C,
Ramos Junior Erivan S,
Fortes Fabio S,
Morandini Ana Carolina F,
Morandi Verônica,
Soeiro Maria de N,
Tanowitz Herbert B,
Scharfstein Julio
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01609.x
Subject(s) - receptor , endothelin 1 , endothelin receptor , biology , bradykinin , internalization , microbiology and biotechnology , trypanosoma cruzi , immunology , parasite hosting , biochemistry , world wide web , computer science
Independent studies in experimental models of Trypanosoma cruzi appointed different roles for endothelin-1 (ET-1) and bradykinin (BK) in the immunopathogenesis of Chagas disease. Here, we addressed the hypothesis that pathogenic outcome is influenced by functional interplay between endothelin receptors (ET(A)R and ET(B)R) and bradykinin B(2) receptors (B(2)R).