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Cannabinoids mediate opposing effects on inflammation‐induced intestinal permeability
Author(s) -
Alhamoruni A,
Wright KL,
Larvin M,
O'Sullivan SE
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01589.x
Subject(s) - endocannabinoid system , cannabinoid receptor , inflammation , pharmacology , cannabidiol , chemistry , cannabinoid , anandamide , receptor , cytokine , biology , immunology , antagonist , biochemistry , medicine , cannabis , psychiatry
Activation of cannabinoid receptors decreases emesis, inflammation, gastric acid secretion and intestinal motility. The ability to modulate intestinal permeability in inflammation may be important in therapy aimed at maintaining epithelial barrier integrity. The aim of the present study was to determine whether cannabinoids modulate the increased permeability associated with inflammation in vitro.