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Inhibiting the TLR4‐MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol‐induced sedation and motor impairment in mice
Author(s) -
Wu Yue,
Lousberg Erin L,
Moldenhauer Lachlan M,
Hayball John D,
Coller Janet K,
Rice Kenner C,
Watkins Linda R,
Somogyi Andrew A,
Hutchinson Mark R
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01572.x
Subject(s) - sedation , medicine , pharmacology , tlr4 , neuroscience , anesthesia , bioinformatics , biology , receptor
Emerging evidence implicates a role for toll-like receptor 4 (TLR4) in the CNS effects of alcohol. The aim of the current study was to determine whether TLR4-MyD88-dependent signalling is involved in the acute behavioural actions of alcohol and if alcohol can activate TLR4-downstream MAPK and NF-κB pathways.