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Combined effects of THC and caffeine on working memory in rats
Author(s) -
Panlilio Leigh V,
Ferré Sergi,
Yasar Sevil,
Thorndike Eric B,
Schindler Charles W,
Goldberg Steven R
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01554.x
Subject(s) - caffeine , adenosine receptor antagonist , antagonist , pharmacology , adenosine receptor , chemistry , adenosine , tetrahydrocannabinol , psychology , cannabinoid , medicine , endocrinology , receptor , biochemistry , agonist
Cannabis and caffeine are two of the most widely used psychoactive substances. Δ(9) -Tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, induces deficits in short-term memory. Caffeine, a non-selective adenosine receptor antagonist, attenuates some memory deficits, but there have been few studies addressing the effects of caffeine and THC in combination. Here, we evaluate the effects of these drugs using a rodent model of working memory.