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Δ 9 ‐Tetrahydrocannabinol (Δ 9 ‐THC) attenuates mouse sperm motility and male fecundity
Author(s) -
Morgan Daniel J,
Muller Charles H,
Murataeva Natalia A,
Davis Brian J,
Mackie Ken
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01506.x
Subject(s) - sperm , sperm motility , biology , andrology , motility , medicine , endocrinology , microbiology and biotechnology , genetics
Numerous studies have shown that N-arachidonoylethanolamine (AEA) can inhibit sperm motility and function but the ability of cannabinoids to inhibit sperm motility is not well understood. We investigated the effects of WIN 55,212-2, a CB(1) cannabinoid receptor agonist, and Δ(9) -tetrahydracannabinol (Δ(9) -THC) on the ATP levels and motility of murine sperm in vitro. In addition, the effects of acute administration of Δ(9) -THC on male fecundity were determined.