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AM630 behaves as a protean ligand at the human cannabinoid CB 2 receptor
Author(s) -
Bolognini Daniele,
Cascio Maria Grazia,
Parolaro Daniela,
Pertwee Roger G
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01503.x
Subject(s) - cannabinoid receptor , cannabinoid , neuroscience , chemistry , receptor , ligand (biochemistry) , cannabinoid receptor type 2 , pharmacology , biology , biochemistry , agonist
We have investigated how pre-incubating hCB(2) CHO cells with the CB(2) receptor antagonists/inverse agonists, AM630 and SR144528, affects how these and other ligands target hCB(2) receptors in these cells or their membranes.