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In vitro and in vivo characterization of PF‐04418948, a novel, potent and selective prostaglandin EP 2 receptor antagonist
Author(s) -
af Forselles KJ,
Root J,
Clarke T,
Davey D,
Aughton K,
Dack K,
Pullen N
Publication year - 2011
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01495.x
Subject(s) - receptor , in vivo , antagonist , receptor antagonist , prostaglandin e2 receptor , chemistry , prostaglandin , agonist , pharmacology , endocrinology , medicine , biology , biochemistry , microbiology and biotechnology
Studies of the role of the prostaglandin EP(2) receptor) have been limited by the availability of potent and selective antagonist tools. Here we describe the in vitro/in vivo pharmacological characterization of a novel EP(2) receptor antagonist, PF-04418948 (1-(4-fluorobenzoyl)-3-{[(6-methoxy-2-naphthyl)oxy]methyl} azetidine-3-carboxylic acid).