Premium
The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear‐conditioned analgesia and controls fear expression in the presence of nociceptive tone
Author(s) -
Olango WM,
Roche M,
Ford GK,
Harhen B,
Finn DP
Publication year - 2012
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01478.x
Subject(s) - endocannabinoid system , nociception , periaqueductal gray , anandamide , rimonabant , context (archaeology) , cannabinoid receptor , psychology , neuroscience , cannabinoid , chemistry , medicine , midbrain , agonist , central nervous system , receptor , biology , paleontology
Endocannabinoids in the midbrain periaqueductal grey (PAG) modulate nociception and unconditioned stress-induced analgesia; however, their role in fear-conditioned analgesia (FCA) has not been examined. The present study examined the role of the endocannabinoid system in the dorsolateral (dl) PAG in formalin-evoked nociceptive behaviour, conditioned fear and FCA in rats.