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Depletion and recovery of lymphoid subsets following morphine administration
Author(s) -
Zhang EY,
Xiong J,
Parker BL,
Chen AY,
Fields PE,
Ma X,
Qiu J,
Yankee TM
Publication year - 2011
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01475.x
Subject(s) - morphine , lymphocyte , bone marrow , lymph , spleen , opioid , immunology , t lymphocyte , lymphatic system , t cell , pharmacology , biology , immune system , medicine , receptor , pathology
Opioid use and abuse has been linked to significant immunosuppression, which has been attributed, in part, to drug-induced depletion of lymphocytes. We sought to define the mechanisms by which lymphocyte populations are depleted and recover following morphine treatment in mice.