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Intermediate‐conductance calcium‐activated potassium channels participate in neurovascular coupling
Author(s) -
Longden TA,
Dunn KM,
Draheim HJ,
Nelson MT,
Weston AH,
Edwards G
Publication year - 2011
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01447.x
Subject(s) - calcium activated potassium channel , potassium channel , potassium , calcium , conductance , biophysics , neuroscience , chemistry , coupling (piping) , neurovascular bundle , medicine , anatomy , materials science , biology , physics , organic chemistry , condensed matter physics , metallurgy
Controlling vascular tone involves K(+) efflux through endothelial cell small- and intermediate-conductance calcium-activated potassium channels (K(Ca)2.3 and K(Ca)3.1, respectively). We investigated the expression of these channels in astrocytes and the possibility that, by a similar mechanism, they might contribute to neurovascular coupling.