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Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways
Author(s) -
Gomez O,
SanchezRodriguez A,
Le MQU,
SanchezCaro C,
MolinaHolgado F,
MolinaHolgado E
Publication year - 2011
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2011.01414.x
Subject(s) - pi3k/akt/mtor pathway , cannabinoid receptor , microbiology and biotechnology , rptor , protein kinase b , neuroscience , signal transduction , chemistry , cannabinoid , biology , receptor , agonist , biochemistry
The endogenous cannabinoid system participates in oligodendrocyte progenitor differentiation in vitro. To determine the effect of synthetic cannabinoids on oligodendrocyte differentiation, we exposed differentiating cultures of oligodendrocytes with cannabinoid CB(1), CB(2) and CB(1)/CB(2) receptor agonists and antagonists. The response of the PI3K/Akt and the mammalian target of rapamycin (mTOR) signalling pathways were studied as effectors of cannabinoid activity.